Congratulating BioE Phd Candidate Chia-Ming (Charles) Wang, who successfully proposed his PhD Thesis

The development of a mesofluidic gut model for studying intestinal mucosal barrier.

In this study, we proposed to develop a human mesofluidic gut model with cells grown on a vertical gel wall, which allows direct visualization of the impact of lumen contents on mucus barrier using a standard fluorescence microscope with optical sectioning capability (e.g., confocal). The ability of this mesofluidic gut model is to study the transport of bacteria and drug carriers within mucus and capture potential changes in the mucus barrier and associated inflammatory response upon exposure to agents we hypothesize to be mucus-disrupting: emulsifiers.