Rebecca Lynn Carrier, Ph.D.
Professor & Associate Chair of Research, Chemical Engineering
Affiliated Faculty, Bioengineering
Affiliated Faculty, Biology
Prof. Rebecca Carrier is a professor at the Northeastern University College of Engineering, Department of Chemical Engineering. She is the recipient of the National Science Foundation CAREER award in 2008 for mechanistic studies and modeling of lipid based drug delivery systems in the GI tract, the NU “Outstanding Teacher” and “Faculty Fellow” Awards in 2011 and 2014 for excellence in teaching and research leadership, and the Soren Buus Outstanding Research Award in 2017. She was invited to participate in the National Academy of Engineering Frontiers of Engineering (2016) and Frontiers of Engineering Education (2013) Symposia. She served as the Member-At-Large for the Society for Biomaterials from 2018-2019, and was inducted into the American Institute for Medical and Biological Engineering in 2019.
Shalom’s work focuses on utilizing in-vitro systems to characterize and develop lipid-mucin effects on transport of drug and peptide-like products. Her current project involves using this framework to predict the impact of dietary lipids on the absorption of oral drugs. She graduated from the University of Delaware in 2022, an serves on the board of Northeastern’s PhD College of Engineering Council.
The role of mucus in performance of formulations is wholly overlooked in bio relevant dissolution systems. Victus’ research focuses on understanding the science behind the potential of mucus and its components to modify drug precipitation behavior in vitro by investigating the mechanism of precipitation inhibition using isothermal titration calorimetry and size exclusion chromatography under a range of different experimental conditions.
Chia-Ming (Charles) Wang
Charles focuses on understanding modulation of the intestinal mucus barrier by food-associated stimuli which potentially disturbs the gut-microbiome-immune homeostasis, leading to intestinal inflammation. In addition, He is developing an intestine-on-a-chip model (mesofluidic gut tube) that enables in situ microscopy of the mucosal interface, and thus visualization of the acute impact of food-associated stimuli on the mucus barrier integrity and transportation/penetration of bacteria, particulates, and signaling molecules through the mucus layer to the underlying intestinal epithelium.
Joshua is working on the development of tissue engineered systems that incorporate the epithelium, immune system, and bacteria. He is interested in the differences between healthy and IBD predisposed tissues and the effects of probiotic intervention on gut health. He is also a member of the Bioengineering Department’s Diversity, Equity, and Inclusion Council.
Peng’s work focuses on (1) Developing a synthetic extracellular matrix system to promote human retinal progenitor cell transplantation into the subretinal space. He is studying retinal cell response (survival, migration, and differentiation) within oxidized alginate hydrogels. (2) Investigating an in vitro retinal cell injection model to better mimic the bolus retinal cell injection present in the clinic. (3) Establishing a model to accomplish live imaging of pig retinal tissue slice.
Ronak’s work focuses on investigating retinal development and disease modeling in vitro. She is working on developing a retina-on-a-chip model to study retina development as well as the interaction between retinal tissue and vasculature in a disease state. In addition, she is working on implementing biomaterials in patterning retinal organoid tissue formation to understand how different microenvironments would affect the proper orientation of different cell types in the neural retina.
Yuan’s research interests include modeling the duodenal tissue with human primary epithelial stem cells and selected commensal bacterial consortia on the microfluidic device and then using the chip model to measure the effects of gastrointestinal fluid mimics as well as different nutritional interventions on the duodenal epithelial inflammatory and metabolic responses.
Durgesh’s research work is focused on analysis of metabolism and transporter activity in organoid derived primary intestinal model. This involves studying the characterization, expression levels of these activities in the model. His work also focuses on understanding the importance of lipid transport and metabolism, due to their importance in drug delivery to lymphatic system. The information gained from project can help in establishing useful invitro screens for understanding drug transport in the body.
Angelie is a 3rd year Bioengineering Major in the Carrier Lab.
Whitney (she/they pronouns) is in her final year of her (first?) chemical engineering degree. She has been working on Dr. Carrier’s “gut team” since the beginning of 2023 with PhD candidate, Matt Fernez, on his project looking at the effects of increased sulfide concentration on the mucosal lining of the microbiome.
Simran is a 3rd year Bioengineering/Biochem Major in the Carrier Lab.