Kordorwu demonstrated that not only does mucus, a natural bio-polymer found in our body, mimic the behavior of biomedical polymers (e.g. HPMC and Kollidon VA 64) in stabilizing supersaturation of poorly soluble drugs but alters the performance of the polymers as well in that regard. This has immense consequences for in vivo performance of supersaturated drug delivery systems. For a better prediction of drug precipitation risk, appropriate mucus activity needs to be incorporated in the characterization and evaluation of supersaturated drug delivery formulations.